Dow Jones Industrial Average Pulls Back On Cyber Monday

The Dow Jones Industrial Average (DJIA) is trading lower, as stocks take a breather after last week's impressive run to all-time highs. Today's pullback -- which isn't necessarily unexpected -- comes even as January-dated crude futures trade up 2.7% at $47.30 per barrel, as major oil players give mixed signals over a potential production cut ahead of Wednesday's Organization of Petroleum Exporting Countries (OPEC) meeting. Meanwhile, absent any significant economic reports, retail stocks are in focus on Cyber Monday, although shares of Amazon.com, Inc. (NASDAQ:AMZN) were last seen trading almost 2% lower.

• What has this drug stock surging almost 20%.
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• Checking in on the CBOE Volatility Index (VIX), the SPDR S&P 500 ETF Trust (SPY), and other noteworthy stats at midday.

• Plus... the drugmaker downed by a bearish brokerage note, the biotech that's nearly doubled, and one of the Nasdaq's biggest losers.

Among the stocks with unusual volume at midday is biotech AstraZeneca plc (ADR) (NYSE:AZN), after a price-target cut from J.P. Morgan Securities. AZN is currently trading down 1.4% at $26.71, with call options crossing at 11 times their average intraday rate -- outpacing puts 22,000 to 1,600.

Biotech PhaseRx Inc (NASDAQ:PZRX) is among the top performers on the Nasdaq, with the shares currently trading 92.9% higher at $2.18. Earlier, the company announced its liver disease treatment, PRX-OTC, has been given an orphan drug designation by the U.S. Food and Drug Administration (FDA). PZRX is a Wall Street rookie, and is on pace to close above its 50-day moving average for the first time ever.

Advanced Accelerator Application SA (ADR) (NASDAQ:AAAP) is among the worst performers on the Nasdaq, currently trading down 9.4% at $30.71. Weighing on the stock is the biotech's mixed earnings report and the FDA's delayed approval for AAAP's Lutathera treatment for neuroendocrine tumors. AAAP is on the short-sale restricted (SSR) list, and is now down 1.8% in 2016.

The CBOE Volatility Index (VIX) is 5.8%, or 0.7 point, at $13.05.

Today's put/call volume ratio on the SPDR S&P 500 ETF Trust (SPY) is at 1.67, with puts leading calls. At last check, SPY was down 0.5 point, or 0.2% at $221.07.

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